For instance, Sakha et al. showed that miR-1246 derived by human oral cancer cells could improve cells’ motility and invasive ability by directly targeting DENN/MADD domain-containing 2D (DENND2D) to activate the ERK and AKT signaling pathways, thereby increasing the incidence of cancer metastasis [34] (Figure 1C). Here, AKT1 is linked to cancer.