Interestingly, in contrast to its role in NPC, Zhang et al. found that TDE-derived miR-9 promotes angiogenesis by activating the JAK-STAT pathway in endothelial cells for various types of cancers, including non-small cell lung cancer, melanoma, pancreatic cancer, and colorectal cancer [49] (Figure 1B). The gene discussed is SOAT1; the disease is nasopharyngeal carcinoma.