For instance, Lee et al. found that macrophages generated from THP-1 induced by phorbol 12-myristate 13-acetate (PMA) are rich in disintegrin and metalloproteinase 15 (ADAM15) and result in delayed tumor growth in vivo, and the tumor volume was also diminished in mice treated with ADAM15-blocked exosomes [62] (Figure 2B), suggesting that ADAM15 exosomes derived from macrophages play a suppressive role in tumor growth and stimulation by PMA for these kinds of macrophages may result in polarization into the M1 phenotype for antitumor effects. This evidence concerns the gene ADAM15 and neoplasm.