Binomial logistic regression analysis in women revealed that SIRT1 rs7895833 AG+GG genotypes are associated with a 1.7-fold increase in the odds of exudative AMD under the dominant model (OR = 1.729; CI: 1.073–2.786; p = 0.024), but this results did not reach statistical significance after Bonferroni correction. This evidence concerns the gene SIRT1 and age-related macular degeneration.