SIRT1 and age-related macular degeneration: The SIRT1 rs3818292 G allele is more common in early AMD than in controls (10.8% vs. 4.5%, p = 0.023), but this result did not reach Bonferroni corrected significance level; also, the same allele was more common in men with exudative AMD than in the controls (12.2% vs. 4.5%, p = 0.006, respectively) (Table 5).