The SIRT1 rs7895833 GG genotype is associated with 5.3-fold (OR = 5.246; CI: 1.187–23.196; p = 0.029), AG+GG genotypes with 1.5-fold (OR = 1.538; CI: 1.064–2.223; p = 0.022) and GG with a 4.8-fold (OR = 4.756; CI: 1.080–20.939; p = 0.039) increased odds of exudative AMD according to the codominant, dominant, and recessive models, respectively. The gene discussed is SIRT1; the disease is age-related macular degeneration.