Based on the fact that ADSC osteogenesis and adipogenesis are in a reciprocal relationship due to the mutual repression of the RUNX2 (master regulator of osteogenesis) and PPARγ (master regulator of adipogenesis) transcription factors [20,21,22], we hypothesize that the suppression of adipogenesis can be the result of activated ADSC osteogenesis in T2DM. Here, RUNX2 is linked to type 2 diabetes mellitus.