MAPK3 and Familial prostate cancer: In prostate cancer and leukemia, many signaling pathways are regulated by active AKT, including extracellular signal-regulated kinase 1/2 (ERK1/2), signal transducers and activators of transcription 3 (STAT3), forkhead box O (FOXO) transcription factors, and Notch1 pathway [15,16].