Previous studies on Apl-1 (Figure 1a) showed its potent cytotoxic activity against HeLa (cervical cancer cells), HCT-116 (colorectal cancer cells), NOMO-1 (acute myeloid leukemia), and HL-60 (promyelocytic leukemia cells) [40,46,47]. The gene discussed is ADI1; the disease is acute promyelocytic leukemia.