As shown in Figure 6, in diabetic rats, the mRNA expression levels of Nrf-2 (Figure 6A) and GLUT4 (Figure 6C) were statistically downregulated in EDL (73.09% and 83.39%, respectively; P < 0.01) and soleus muscle (57.26% and 70.51%, respectively; P < 0.05) compared to the control group, while treatment with apocynin significantly enhanced Nrf2 and GLUT4 expressions in both EDL (75.66%) and soleus muscles (69.54%) compared to the diabetes group. This evidence concerns the gene SLC2A4 and diabetes mellitus.