ELN and aortic stenosis: ELN rs2071307 variant has been associated with other multifactorial ECM conditions, such as aortic stenosis [69] and aortic aneurysm [70]ELN rs2071307 and FBN2 rs331079 variants associate with aortic and intracranial aneurysms, respectively, causing ECM disruptionFibrillin-1 abnormalities have been associated with Marfan’s syndrome and Fibrillin-2 have with Beal’s syndrome or congenital contractural arachnoldactyly [71,72]