VWF and acute coronary syndrome: To determine early endothelial dysfunction status, von Willebrand factor (vWF) was measured, as this has been described as an acute-phase reactant, indicative of endothelial homeostasis disturbance [29], whereas leucoglycemic index (LGI) is a systemic inflammatory marker broadly used as a predictive parameter of poor cardiovascular prognosis in myocardial infarction [30,31], acute coronary syndrome [32], and atherothrombotic cerebral ischemia [33].