H19 and obesity due to melanocortin 4 receptor deficiency: In humans, lncRNA H19 expression is detected in both subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), and its level positively correlates with markers of adipose tissue browning such as mRNA of UCP1; in people with obesity, SAT and VAT levels of lncRNA H19 decrease with increasing BMI [12].