IL4 and allergic rhinitis: Shumna et al. analyzed the relationship of the IL-4 T589C polymorphism with bronchial asthma, allergic rhinitis, and orthodontic pathology and concluded that the CC genotype of the IL-4 gene is associated with bronchial asthma (OR = 4.31; 95% CI = 1.63–11.36; p = 0.002) and allergic rhinitis (OR = 4.32; 95% CI = 1.04–7.81; p = 0.04) [32].