Although some studies have classified drusen according to their morphology or according to their content in relation to other neurodegenerative diseases [4,28,29], to our knowledge, this is the first study that makes a morphological classification of drusen that appears in subjects with high genetic risk of developing AD, i.e., who are carriers of at least one ɛ4 allele for the ApoE gene and have a family member affected by sporadic AD, classifying them by the presence of comorbidities such as hypercholesterolemia, arterial hypertension, and diabetes. This evidence concerns the gene APOE and diabetes mellitus.