When we compare the low PSMA expression cohort of Rosenzweig to a truly PSMA-negative cohort, we see that a similar proportion of patients have pT3 disease (46% vs. 60%), but the proportion of ISUP 5 disease was higher in the PSMA-negative cohort (3.8% vs. 27%), suggesting that PSMA-negative PCa is a different entity. Here, FOLH1 is linked to posterior cortical atrophy.