Therefore, we speculated that the four LoF mutations (GRIK1p.Phe24fs, GRIK1p.Thr882fs, GRIK2p.Arg300Ter, and GRIK4p.Gln342Ter) that we identified from patients with schizophrenia may affect the binding of the kainate receptors with PSD95 protein. This evidence concerns the gene DLG4 and schizophrenia.