PRKN and Parkinson disease: Three dysregulated miRNAs (miR-34b, miR-218, miR-221) interact with PD-related genes (DJ1, PRKN, SNCA) and modulate their functions in different PD cellular and animal models, while others (miR-133b, miR-126, miR-132, miR-144, miR-425 and miR-124) participate in neuronal apoptosis and survival signaling pathways, as well as in autophagy mechanisms (Table 2).