In PD models, miR-218 plays a role in modulating the NF-κB inflammatory signaling pathway, by influencing the activity of three importins, KPNB1, KPNA3, and KPNA4 [107], and interacts with the PD related gene PRKN [269], leading to mitochondrial dysfunction through the autophagic pathway [188] (Table 2, Figure 2). The gene discussed is PRKN; the disease is Parkinson disease.