APP and Alzheimer disease: Up-regulated in hippocampal CA1 region [35,54], temporal lobe neocortex (Brodmann area A22) [36], cerebellum, hippocampus, medial frontal gyrus [25], frontal cortex (Brodmann areas 6 and 8) [63], iPSC-derived iNEU-PSEN hippocampal neuron from the AD patient [59], and APP and PS1 variants of hippocampal spheroids differentiated from iPSC (3D hippocampal structures) [64]; down-regulated in grey matter [28]