Increased serum level of miR-133b in ALS may influence skeletal muscle development [203,280] and neuromuscular junction maintenance/reinnervation [230,231] and targets several ALS-related genes, such as CCL2, CD4, FAS, EIF2C4/AGOA and AQP1 [212] (Table 3, Figure 2). The gene discussed is AGO4; the disease is amyotrophic lateral sclerosis.