In particular, it represents one of the most-studied miRNAs in AD and, together with its downstream molecular targets (HDAC3, ITPKB, p250GAP, HNRNPU, PTBP2, and SIRT1), is involved in the regulation of two AD pathological hallmarks: tau and Aβ [72,73,74,75,76,77,78] (Table 1, Figure 2). The gene discussed is SIRT1; the disease is Alzheimer disease.