VEGFA and coronary artery disorder: Especially, one study showed that circulating levels of total VEGF-A and VEGF-A165b in CAD patients were associated with syntax score, indicating the severity and complexity of CAD [30], and another study showed that VEGF 165b induced a neovascular response in the adventitia, and enhanced intimal thickening through the peri-adventitial collar placement [31].