Vascular endothelial growth factors (VEGFs, e.g., VEGF-A, VEGF-B, VEGF-C, VEGF-D) and the receptor tyrosine kinases (RTKs) VEGFR-1, VEGFR-2, and VEGFR-3 are crucial for the promotion of tumor angiogenesis [15,16]. The gene discussed is VEGFA; the disease is neoplasm.