ADIPOQ and obesity due to melanocortin 4 receptor deficiency: However, the men with T2DM with obesity in group C presented significantly high levels of leptin compared to the controls and groups A and B, with p < 0.01, whereas the men with T2DM in group D with severe obesity demonstrated significantly high levels of adiponectin compared to the controls and groups A and B, with p < 0.001.