IGHE and asthma: The main criteria in most of these reports include non-fully reversible airflow limitation, a history of asthma diagnosed before the age of 40 years, persistent symptoms that vary and progress over time, smoking history ≥ 10 years or significant exposure in other noxious particles or gases, high levels of eosinophils in sputum and/or in blood, exhaled breath nitric oxide (FeNO) levels ≥ 45 to 50 ppm, history of atopy or high IgE for total serum or inhaled allergens, metacholine challenge test positivity, and significant bronchodilation response [17].