Blood examinations: Elevated levels of serum immunoglobulin-E (i.e., IgE >100 IU/mL), or peripheral blood eosinophil count (>300 cells/mL), accompanied by evidence of allergic disease (e.g., skin testing or immunoassays for perennial allergen sensitivity) may indicate an asthma or ACO diagnosis. This evidence concerns the gene IGHE and asthma.