Intrigued by the observation that chondroitin sulphate accumulates in the Golgi apparatus of tumor cells and retinoic acid alters the Golgi apparatus morphology, Li and co-workers designed a nano formulation based on paclitaxel, chondroitin sulphate, and retinoic acid (PTX-CS–RA), which showed anti-metastatic effects by inhibiting metastasis-associated proteins through Golgi apparatus disruption and reduced tumor growth in 4T1 cells [129]. This evidence concerns the gene CS and neoplasm.