Conversely, hypomethylation and upregulated oncogene functions of HIST1H3I (Histone linker 1 with Histone H3.1), HIST1H3D (Histone linker 1 with Histone H3.D) [53,54,55,56], NFATC4 (Nuclear factor of activated T-cells cytoplasmic 4) [57,58,59,60] and HOXB8 (Homeobox B8) [61,62,63] were associated with adiposity and colon cancer. This evidence concerns the gene HOXB8 and colonic neoplasm.