ESR1 and neoplasm: In our study, only patient’s age, mitotic index, and the presence of at least one HR (ER or PR) were considered to be prognostic factors for OS by multivariate analysis, while PTEN mutation was recently reported to be correlated with favorable prognosis in EC patients and found to be associated with immune infiltrating cells, such as Tregs and M1 macrophages, in the tumor microenvironment [61].