More than three-quarters of the study population (78.0%) had an ischemic etiology of HF and 27.5% had at least one HF hospitalization in the previous 12 months, with a mean LVEF of 34.1 ± 8.3% and a median baseline NT-proBNP value of 781.0 (350.7–1599.1) pg/mL. This evidence concerns the gene NPPB and hydrops fetalis.