Several studies have reported that SPP1 is a predictor and biomarker of prognosis of HBV-related ACLF [56,57], because the serum level of SPP1 is significantly higher in HBV-related ACLF patients compared with that in cirrhosis patients and HCs and is positively correlated with the ACLF severity, which is consistent with our results for SPP1 expression measured by qRT-PCR and IHC. The gene discussed is SPP1; the disease is Cirrhosis.