JAK2 and rheumatic disorder: Curcumin is also able to inhibit the Janus Kinase 2/Signal Transducers and Activators of Transcription (JAK2/STAT) pathways in different types of myeloproliferative neoplasms [34], a finding that is remarkable given the growing relevance of JAK/STAT-inhibition in the treatment of rheumatic diseases.