Along this line, it was demonstrated in the same study [34] that genes encoding for components of the TCR, for co-stimulatory molecules (CD28) and proteins implicated in T-cell activation pathways (NFATC1, NFATC2, PPP3CC), were also hypomethylated in GCA arteries when compared to non-GCA arteries [34]. The gene discussed is NFATC2; the disease is temporal arteritis.