HLA-DRB1 and temporal arteritis: More recently, a study including 184 patients with cranial GCA, 105 patients with large-vessel GCA and 486 healthy controls showed an association between the HLA-B*15:01 allele and GCA, regardless of the clinical phenotype of the disease, and that there was an increased risk of developing GCA, whatever its phenotype, if HLA-B*15:01 and HLA-DRB1*04:01 were expressed together [30].