Activation of CD8+ T lymphocytes was evaluated through the expression of the degranulation marker CD107a, which was significantly reduced 1.5- (p = 0.0271) and 1.8-fold (p = 0.0014) in individuals with CLL and MM, respectively, in comparison with healthy donors, and did not change after vaccination (Figure 5B, right graph). This evidence concerns the gene LAMP1 and Miyoshi myopathy.