In the highly-sensitive cTn era, detectable cTn using these highly sensitive cTn assays in non-HF patients is quite common, and elevated values are associated with increased all-cause death, cardiovascular death, and incident HF after adjusting renal function, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (CRP) [30,31,32]. The gene discussed is NPPB; the disease is hydrops fetalis.