In the Cox proportional hazard model, a history of hypothyroidism and biomarkers (D-dimer ≥ 0.8 μg/mL, lactic dehydrogenase ≥ 430 IU/L, CRP ≥ 4.83mg/dL, and triglycerides ≥ 214 mg/dL) were significantly associated with increased mortality. The gene discussed is CRP; the disease is hypothyroidism.