PMP22 and Charcot-Marie-Tooth disease type 1A: Unequal crossover due to misalignment during meiosis in the ch17p11.2 region leads to CNVs comprising the PMP22 gene that are associated with either Charcot–Marie–Tooth (CMT1A) disease (PMP22 duplication) or hereditary neuropathy with liability to pressure palsy (HNLP) diseases (PMP22 deletion) [48].