The recent guidelines of the European Association of Urology (EAU), European Association of Nuclear Medicine (EANM), European Society for Radiotherapy and Oncology (ESTRO), European Society of Urogenital Radiology (ESUR), and International Society of Geriatric Oncology (SIOG) on prostate cancer [11] strongly recommend early PSA testing to well-informed men at elevated risk of having PCa, including men from 50 years of age, men from 45 years of age with a family history of PCa, men of African descent from 45 years of age, and men carrying BRCA2 mutations from 40 years of age. The gene discussed is KLK3; the disease is Familial prostate cancer.