In the synovial membrane, the mean of IRS for adiponectin was strongly positive in the RA and OA groups (9 and 8), for AdipoR1 it was strongly positive in the RA group and weakly positive in the OA group (8 vs.6), and for AdipoR2 it was weakly positive in the RA and OA groups (6 vs.4). Here, ADIPOR1 is linked to rheumatoid arthritis.