Definitions of remission vary in the large publications; the UK Surveillance study defined complete remission as normal factor VIII, undetectable inhibitor, and stopped immunosuppression or immunosuppression reduced to the doses used before the development of the acquired haemophilia without relapse [16]; in EACH2 CR is the clearance of the autoantibody and stable FVIII activity of >70 U dL−1 without replacement therapy; the term of “stable remission” is also included for cases which required the continuation of IST [17]. Here, F8 is linked to hemophilia.