Several hundred variants of the ENG and ACVRL1 genes, including deletions, duplications, missense and nonsense mutations, splice defects, and silent variants, have been identified in patients with HHT [8,9] and are present in HHT mutation databases (http://arup.utah.edu/database/ENG/ENG_welcome.php, accessed on 7 March 2022) [10]. This evidence concerns the gene ACVRL1 and hereditary hemorrhagic telangiectasia.