Both Il1a and Illb transcripts were upregulated in the Il17ra−/− HNI + OPC mice compared to WT (Figure S4C,D) and may account for the increased neutrophil influx in the tongue tissue, which is similar to the role of IL-1α and IL-1β at the peak of damage during oral mucositis caused by HNI-only in Il17ra−/− mice [28]. Here, IL1A is linked to oral mucositis.