However, expanded NKG2A+ NK cells from the same donors having the KIR2DS4 allele failed to develop a cytotoxic response towards HT18584 and HT18816 GBM target cells with expression of cognate C*02:02 and C*05:01 ligands, respectively, which might indicate the absence of aKIR-mediated alloreactivity in both differentially expanded NK cells. This evidence concerns the gene KLRC1 and glioblastoma.