From our point of view, the most important phosphatase was PTPRK, as we observed its downregulation in 17 drug-resistant ovarian cancer cell lines [26], and others observed that downregulation of PTPRK correlates with poor prognosis in breast cancer [96] and worse response to chemotherapy in nasal-type NK/T-cell lymphoma (NKTCL) [97]. The gene discussed is PTPRK; the disease is breast cancer.