GBA1 and Mental deterioration: It is tempting to correlate the involvement of Lewy pathology in hippocampal regions in GD-LBD with the more pronounced cognitive decline seen in GBA1-PD patients, but in asmuch as since hippocampal involvement is also observed in LBD without GBA1-mutations, more cases need to be examined to conclude whether the spread of LB pathology differs from sporadic cases [55].