ZAP70 and B-cell chronic lymphocytic leukemia: While miR-32-5p, miR-98-5p, miR-145-5p, miR-185-5p, miR-192, and miR-374b-5p are potential biomarkers for the early detection of CLL [19,106,107], a miRNA expression signature composed of 13 genes can differentiate between subgroups of CLL patients, based on the level of ZAP-70 expression and immunoglobulin heavy chain variable region gene (IgHV) mutational status [5].