Overexpression of miR-125b-5p sensitized cutaneous T-cell lymphoma cells to bortezomib via modulation of MAD4 protein [21], while miR-223-3p is implicated in ibrutinib resistance through regulation of the conserved helix-loop-helix ubiquitous kinase (CHUK)-NFκB signaling pathway in mantle cell lymphoma [177]. The gene discussed is CHUK; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.