CD274 and neoplasm: (c) The NLRP3 pathway: the programmed death-ligand 1/NOD-, LRR-, and pyrin domain-containing protein 3 (PD-L1/NLRP3) inflammasome signaling cascade [97], in cooperation with CXCR2, leads to the recruitment of granulocytic myeloid-derived suppressor cells (PMN-MDSCs) into tumor tissues, thereby blunting the T cell response.