SLC5A2 and heart failure: The mechanism of action, underlying the effect of SGLT-2 inhibitors in decreasing BP is not fully understood; however a multifactorial action has been postulated including osmotic and natriuretic diuresis and decrease in arterial stiffness and sympathetic tone [97]; their mechanism of action supports the hypothesis according to which reduction of risk of heart failure is higher than the atherothrombotic-related effects [98].