In a physiologic state, Treg cells inhibit osteoclastogenesis through anti-inflammatory cytokines (such as IL-10) and CTLA4 signaling (a negative regulator of T-cell activation) [15]; it has been found that IL-6 produced by dendritic cells inhibits Treg cell function in mouse SLE models [18]. This evidence concerns the gene IL6 and systemic lupus erythematosus.