TNF and ocular melanoma: Recently, Xie et al. analyzed several single-nucleotide polymorphisms (SNPs) of DNA sequences linked to the susceptibility of OM and they reported that the SNPs in IL1B, IL6, IL4, IL10, IL12B, IL1A, IFNG, TNF, PTGS2 (prostaglandin-endoperoxide synthase 2), CTSG (cathepsin G), VDR (vitamin D receptor), MMP1 (matrix metalloproteinase 1), PLAT (plasminogen activator, tissue type), and BAX (Bcl-2 associated X) increased the risk of bacterial OM, whereas those in IL1RN (IL-1 receptor antagonist) and TLR2 (toll-like receptor 2) could protect against OM [66].