ZAP70 and Alzheimer disease: Thirteen inflammatory genes were over-expressed in the hippocampus of AT mice as compared with WT controls, while four genes were down-regulated (Tnfaip3, Erg1, Csf2 and Zap70), as presented in Figure 1A. Some of these genes underlie basic pathological processes in the AD brain, such as apoptosis (Casp8, Tnfsf10, Birc3 and Tnfaip3) and DNA damage responses (Atr, Ercc6 and Rag2).