The significantly different phosphoprotein/protein ratios, particularly those suggesting inhibition of phosphorylation (diminishing ratios when compared to the NGT group), were enriched for extracellular matrix-receptor interactions pathways, immune-related pathways involved in fighting infection, as well as PI3K-Akt signaling and Rap1 signaling pathways, among others (Figure 2A). Here, AKT1 is linked to infection.