On the other hand, phosphorylated ITGA2 and total ITGA6 protein were highly upregulated in the T2DM group (Figure 4E,F and Figure 6H,I), which suggests that T2DM might be associated with a switch of integrin surface molecules in EVs and, possibly, in the originating cells. The gene discussed is ITGA6; the disease is type 2 diabetes mellitus.