Interestingly, upstream activation of STK4 (a major signaling kinase of the Hippo pathway [30]) appears to be the single kinase responsible for the increased phosphorylation of MYLK, one of the kinases that were central to the upregulated phosphoprotein network in T2DM (Figure 4E), as compared to the NGT group. The gene discussed is STK4; the disease is type 2 diabetes mellitus.