On the other hand, PKCδ has been reported to promote insulin secretion from the pancreatic β cell by increasing the number of insulin granules in the ready-releasable pool [57] and to be elevated in the liver of mice and humans with obesity, where it plays an important role in the development of hepatic insulin resistance and hepatosteatosis [58,59]. The gene discussed is PRKCD; the disease is obesity due to melanocortin 4 receptor deficiency.