NLRP3 and major depressive disorder: In the present study, the DNA methylation levels of NLRP3 were significantly correlated with cortical thickness in the various regions of the brain that showed significantly greater or lower cortical thickness in MDD patients compared to HCs, such as the bilateral lingual gyrus, the left superior occipital gyrus, the right postcentral gyrus, the right middle temporal gyrus, the right planum temporale, and the left superior frontal gyrus.