ALCAM and cancer: Furthermore, the capacity of “ALCAM-KO/SKOV-3 EVs” to support the adhesion of SKOV-3 cells was also greatly reduced (21% adherent cells) compared to that of ALCAM-expressing “SKOV-3 EVs” (35% adherent cells), indicating that ALCAM on the EV surface is also involved in the interactions between cancer cells and EVs.