ALCAM and colorectal carcinoma: To exclude the possibility that the observed involvement of ALCAM in the interactions between SKOV-3 cells and the SKOV-3-derived EVs was a particularity of this ovarian carcinoma cell line and their EVs, we also carried out similar adhesion experiments with the colorectal carcinoma Colo-320 cells (either expressing ALCAM or not) and EVs derived from them (either expressing ALCAM or not).