LOXL3 and Hearing impairment: Human LOXL3 has been proposed as a candidate gene responsible for recessive autosomal Stickler syndrome [28], a collagenopathy characterised by bone and cartilage abnormalities as well as by different degrees of hearing impairment [29] that might also cause imbalance, similar to the instability we observed in Loxl3 KO adult mice.