In the case of DDD related pain, pathological IVD changes when coupled with increased levels of IL-1β, TNFα, IL-6, and IL-8 within the degenerative disc can induce IVD NP cells to synthesize NGF and BDNF and lead to pain of IVD origin [11,19]. The gene discussed is BDNF; the disease is Dowling-Degos disease 1.