GH1 and hypogonadism: They favour a negative calcium balance by decreasing intestinal calcium absorption and stimulating renal tubular calcium excretion in the urine; they interfere with the growth hormone (GH)–insulin growth factor (IGF1) axis, leading to altered growth plate chondrocyte function and to GC-induced myopathy; they also interfere with gonadotropin secretion, causing hypogonadism and delayed puberty [103].