In a meta-analysis (enrolling more than 8000 CRC cases and 6000 controls) Picelli, et al. revisited the associations of rs3219484:G–A (MUTYH V22M) and rs3219489:G-C (MUTYH Q338H) polymorphisms with the risk of sporadic CRC with negative outcomes [43]. Here, MUTYH is linked to colorectal carcinoma.