Here, we provide molecular characteristics of two major BER glycosylases MUTYH and hOGG1 in tissue samples of sporadic CRC patients in relation to a characteristic mutational signature (G:C > T:A transversion in oncogenic KRAS gene) with specific aim to assess the role of BER glycosylases on the pathogenesis of sporadic CRC. This evidence concerns the gene MUTYH and colorectal carcinoma.