Interestingly, only 3 somatic substitutions c.38C>T (p.A13V) [rs587780747], c.141G>A (p.K47K) and c.695C>T (p.T232I) in MUTYH gene (NM_001128425) have been detected in the tumor tissue; however, with no unambiguous pathological effect on the protein. This evidence concerns the gene MUTYH and neoplasm.