NLRP3 and injury: Therefore, in this study, 3-methyladenine (3-MA, an inhibitor of autophagy) or rapamycin (RAPA, an inducer of autophagy) was used to regulate autophagy in realgar- induced liver injury mice model to explore the function of autophagy in realgar-induced liver injury and elucidate the relationship between autophagy and NLRP3 inflammasome activation in liver tissues.