ASPS is characterized by a specific, unbalanced translocation der(17)t(X;17)(p11;p25), resulting in the formation of the alveolar soft part sarcoma critical region 1-transcription factor E3 (ASPSCR1-TFE3) fusion that transcriptionally upregulates MET, which leads to overexpression of the MET receptor [5]. Here, TFE3 is linked to alveolar soft part sarcoma.